January 2019 - New NIH R01 funding via UMMC collaboration
Congrats to PIs Dr. Sunjay Kaushal and Peixin Yang of the University of Maryland Medical Center on their new R01 from the National Heart, Lung, and Blood Institute (NHLBI)! As collaborators on this project, our work will focus on purification, drug loading, and delivery of cardiac progenitor cell-derived exosomes to promote heart recovery after cardiac injury.
January 2019 - Eli Pottash awarded NIH T32 Fellowship
Congrats to Eli on being selected for a fellowship position on UMD's Host-Pathogen Interactions training grant from the National Institutes of Health! This award via the National Institute of Allergy and Infectious Diseases (NIAID) will support Eli's work on developing new biomimetic and bioinspired nucleic acid delivery systems.
December 2018 - New publication
Congrats to Eli, Chris, and Madeleine on the acceptance of their review article on protein-based vehicles for biomimetic RNAi delivery in the Journal of Biological Engineering (link soon!), published as part of a special issue for Emerging Leaders in Biological Engineering!
November 2018 - New publications
Congrats to Divya for her new paper in Acta Biomaterialia, published as part of a special issue on Cell and Tissue Biofabrication!
Also note the new position statement from ISEV on minimal information for studies of extracellular vesicles (MISEV2018)
Also note the new position statement from ISEV on minimal information for studies of extracellular vesicles (MISEV2018)
October 2018 - New publications
Congrats to Tek and Divya for their new papers in Methods in Molecular Biology and Biotechnology Advances, respectively.
Congrats also to our collaborators Dr. Wei Chao and Dr. William Bentley.
Access Tek's paper here: Production of Extracellular Vesicles Loaded with Therapeutic Cargo
Access Divya's paper here: Towards Rationally Designed Biomanufacturing of Therapeutic Extracellular Vesicles: Impact of the Bioproduction Microenvironment
With the Chao group: Circulating plasma extracellular vesicles from septic mice induce inflammation via miRNA- and TLR7-dependent mechanisms
With the Bentley group: Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease
Congrats also to our collaborators Dr. Wei Chao and Dr. William Bentley.
Access Tek's paper here: Production of Extracellular Vesicles Loaded with Therapeutic Cargo
Access Divya's paper here: Towards Rationally Designed Biomanufacturing of Therapeutic Extracellular Vesicles: Impact of the Bioproduction Microenvironment
With the Chao group: Circulating plasma extracellular vesicles from septic mice induce inflammation via miRNA- and TLR7-dependent mechanisms
With the Bentley group: Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease
August 2018 - Rachel joins the group
Welcome to Rachel Lee, a MS student working on EV biomanufacturing!
July 2018 - Anjana wins BMES Career Development Award
Congrats to Anjana Jeyaram for being selected for a 2018 BMES Career Development Award, which provides a complimentary registration to the 2018 BMES Annual Meeting and a travel stipend! Anjana will be presenting her work on enhancing the therapeutic efficacy of extracellular vesicles via co-loading of miRNA cargo.
July 2018 - Divya wins BMES Travel Award
Congrats to Divya Patel for being selected for a podium presentation and winning a Student Travel Award to the BMES Annual Meeting in Atlanta in October!
June 2018 - Louis joins the lab
Welcome to Louis Born, a MD/PhD student starting his PhD phase in the lab this summer with a prestigious A. James Clark Doctoral Fellowship!
June 2018 - Anjana wins Best Poster award at World Preclinical Congress
Congrats to Anjana Jeyaram for winning the judges' award for Best Poster at the 2018 World Preclinical Congress!
June 2018 - John departs for U. Michigan
Dr. John Schardt leaves for his postdoc with Dr. Peter Tessier at the University of Michigan. He will be missed!
May 2018 - John wins 2nd prize in Dean's Doctoral Research Award Competition
Congrats to Dr. John Schardt for placing 2nd in the Clark School Dean's Doctoral Research Award Competition. John was the sole nominee from Bioengineering and received a $1000 prize for his efforts. Great job!
May 2018 - Congrats to senior Capstone students!
Lab undergrads Natalie Livingston and Sonya Williams successfully completed their senior Capstone project presentations. Here's Natalie modeling her team's project...the newest addition to the Ironman suit?
April 2018 - Madeleine Noonan-Shueh awarded ASPIRE Fellowship for Summer 2018
This award will enable Madeleine to continue her protein therapeutics work in the lab. Congrats!
April 2018 - Dr. Jay named UMD Graduate Faculty Mentor of the Year
Thanks to all of the graduate students in the lab for the nomination.
April 2018 - Successful BIOE Honors Thesis Defenses
Congrats to Sonya Williams and Natalie Livingston for their successful defenses of their BIOE Honors Theses!
April 2018 - Congrats Dr. John Schardt!
John becomes the first PhD recipient from the lab, and all he had to do was design, express, purify, and test ~25 different proteins. Congrats!
April 2018 - Lab research recognized with CDMRP PRMRP funding recommendation
Thanks to the CDMRP Peer-Reviewed Medical Research Program for the recognition of our efforts to develop EV-based treatments for diabetic wounds.
April 2018 - Natalie Livingston awarded NSF Graduate Fellowship; Eli Pottash receives Honorable Mention
Congrats to Natalie and Eli! UMD News Article
March 2018 - Lab moves to A. James Clark Hall
We're excited for our new space in Rm 3113 of the recently opened A. James Clark Hall!
March 2018 - Lab receives NIH R01 funding
Thanks to the NHLBI for supporting our work on controlled RNA delivery via EVs. UMD News Article
March 2018 - Dr. Jay receives NSF CAREER Award
Thanks to the NSF for supporting our work on therapeutic EV biomanufacturing. UMD News Article
March 2018 - Lab receives funding from the Rivkin Center for Ovarian Cancer
Thanks to the Rivkin Center for supporting our work on HER3-targeted therapeutics for ovarian cancer treatment.
March 2018 - Sonya Williams win Honors College Research Award
Congrats to Sonya for winning this award to support her BIOE Honors thesis research!
February 2018 - Jinan Oubaid wins Mtech Outstanding ASPIRE Student Research Award
Congrats to Jinan for winning 1 of 2 awards from Mtech recognizing her outstanding research contributions!
February 2018 - Natalie and Sonya win departmental awards
Two of our senior undergrad students received departmental awards, congrats and well deserved!
Fischell Outstanding Research Award: Natalie Livingston
Fischell Outstanding Citizen Award: Sonya Williams
UMD News Article
Fischell Outstanding Research Award: Natalie Livingston
Fischell Outstanding Citizen Award: Sonya Williams
UMD News Article
February 2018 - Sonya Williams awarded ASPIRE fellowship for Spring 2018
This award will enable Sonya to continue her protein therapeutics work in the lab until graduation this May. Congrats!
January 2018 - Dr. Jay named Associate Scientific Advisor for Science Translational Medicine
Early-career translational scientists are annually selected to serve for a period of 1 year to act as advisors for the journal and select and summarize research papers to be highlighted in the Editors' Choice section.
December 2017 - Anjana Jeyaram receives PhRMA Predoctoral Fellowship
Anjana was awarded a 2 year fellowship from the Pharmaceutical Research and Manufacturers Association (PhRMA) Foundation to study pharmaceutical and translational properties of extracellular vesicles! UMD News Article
November 2017 - Special Issue in Tissue Engineering on EVs
Tissue Engineering has published a Special Focus Issue on the Emerging Impact of Extracellular Vesicles on Tissue Engineering and Regeneration, guest edited by Steven M. Jay, PhD and Gordana Vunjak-Novakovic, PhD.
October 2017 - New publications on EVs
Congrats to Tek and Anjana for their new papers in Scientific Reports and AAPS Journal, respectively.
Congrats also to our collaborators Dr. Zhengguo Xiao and Dr. Catherine Fenselau!
Access Tek's paper here: Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs
Access Anjana's paper here: Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications
With the Fenselau group: Ubiquitin Conjugation Probed by Inflammation in Myeloid-Derived Suppressor Cell Extracellular Vesicles
With the Xiao group: IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells
Congrats also to our collaborators Dr. Zhengguo Xiao and Dr. Catherine Fenselau!
Access Tek's paper here: Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs
Access Anjana's paper here: Preservation and Storage Stability of Extracellular Vesicles for Therapeutic Applications
With the Fenselau group: Ubiquitin Conjugation Probed by Inflammation in Myeloid-Derived Suppressor Cell Extracellular Vesicles
With the Xiao group: IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells
August 2017 - Tek Lamichhane joins Medigen as Assistant Director
Congrats to Tek on his new job! Tek's contributions to the lab over 3+ years have been tremendous and he will be missed, but we wish him well in his new position.
July 2017 - Team MATRIX awarded funding from Alpha Omicron Pi
Congrats to Team MATRIX on receiving an Arthritis Foundation grant from the Alpha Omicron Pi Foundation to support their work studying potential therapeutic applications of EVs in osteoarthritis!
June 2017 - Chris Kuffner admitted to BIOE Honors Program
Chris was accepted into the BIOE Honors Program to perform research for the next 2 years on developing RNA therapeutics. Congrats Chris!
June 2017 - New Publication in Bioengineering and Translational Medicine
Divya's paper, entitled "Impact of Cell Culture Parameters on Production and Vascularization Bioactivity of Mesenchymal Stem Cell-Derived Extracellular Vesicles" was accepted in BioTM! This work, which was co-authored by Kelsey Gray and performed in collaboration with the laboratory of Kimberly Stroka at UMD, shows that cell passage and density impact the therapeutic and translational potential of MSC EVs. Great work all!
Access Divya's paper here: BioTM and the BioTM Buzz article featuring the work here: BioTM Buzz
Access Divya's paper here: BioTM and the BioTM Buzz article featuring the work here: BioTM Buzz
June 2017 - Lab receives funding from MPower Nervous System Injury and Neuroscience Initiative
This award with co-PI Junfang Wu from the University of Maryland School of Medicine enables study of exosome-based approaches to treatment of spinal cord injury.
June 2017 - Lab receives funding from Maryland Innovation Initiative
This award as a collaborator with Dr. John Harmon of Johns Hopkins University and Canton Biotechnologies facilitates the study of DNA delivery for wound repair.
May 2017 - John Schardt receives AAPS Graduate Student Fellowship
This award, 1 of only 6 awarded nationally, will support John's work on HER3 inhibitors for cancer therapy. Congrats! UMD News Article
May 2017 - Anjana Jeyaram advances to PhD candidacy
Congrats to Anjana, who successfully passed her PhD proposal examination and is now officially a PhD candidate!
April 2017 - New publication in ATVB
Collaborative work with the group of Yale Surgeon Dr. Alan Dardik published in Arteriosclerosis, Thrombosis, and Vascular Biology: CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation.
April 2017 - Divya Patel advances to PhD candidacy
Congrats to Divya, who successfully passed her PhD proposal examination and is now officially a PhD candidate!
April 2017 - Jinan Oubaid awarded ASPIRE scholarship for summer 2017
This award will enable Jinan to continue her protein therapeutics work in the lab. Congrats Jinan!
April 2017 - Sri Ayyagari defends BIOE Honors Thesis
Congrats to Sri, who successfully defended her BIOE Honors thesis! She becomes the first BIOE Honors awardee from the lab.
April 2017 - Natalie receives Honorable Mention in Goldwater Scholarship competition
Natalie Livingston was awarded a prestigious Honorable Mention in the Barry M. Goldwater Scholarship competition. Congrats Natalie!
March 2017 - New publication in Molecular Pharmaceutics
John's paper "Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells" was published in Molecular Pharmaceutics.
March 2017 - Sonya Williams receives Maryland Summer Scholars award
This award will support Sonya's work in the lab this summer!
February 2017 - John Schardt receives 2017 PEGSummit Student Fellowship
This award will support John's attendance at PEGS Boston, one of the premier protein engineering conferences in the world.
January 2017 - Eli joins the lab
Welcome to the newest PhD student in the group, Eli Pottash.
December 2016 - Lab receives funding from the Elsa U. Pardee Foundation
This award supports our work on HER3-targeted therapy in collaboration with Stan Lipkowitz at the NCI.
October 2016 - Lab receives funding from the National Cancer Institute (NCI)
This award, made through the University of Maryland Marlene and Stewart Greenebaum Cancer Center, supports our research on HER3-targeted therapies along with our collaborators Dr. Arif Hussain and Dr. Rena Lapidus.
August 2016 - Dr. Jay named Cellular & Molecular Bioengineering Young Innovator for 2016
Thanks to the hard work of everyone in the group, Dr. Jay was recognized with this honor alongside 10 talented colleagues. More info here: CAMB Young Innovators Issue
July 2016 - New Publication in Cellular and Molecular Bioengineering
Tek's paper "Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication" was published in Cellular and Molecular Bioengineering as part of the 2016 Young Innovators special issue.
June 2016 - Divya Patel receives AHA Predoctoral Fellowship
Divya was awarded a 2 year fellowship from the American Heart Association to study the effects of cellular mechanical microenvironment on EV biogenesis and vascularization bioactivity! UMD News Article
