Publications (Pubmed)(Google Scholar)
Jay Lab at UMD
38. Lamichhane TN; Jay SM. (2018) Production of Extracellular Vesicles Loaded with Therapeutic Cargo. Methods in Molecular Biology 1831:37-47.
37. Jay SM (2018) A New Hope for chronic myocardial ischemia. Science Translational Medicine 10(449):eaau1975
36. Jay SM (2018) Slow and steady wins the race. Science Translational Medicine 10(441):eaat8530
35. Jay SM (2018) An EVolving approach to directed enzyme prodrug therapy for cancer. Science Translational Medicine 10(433):eaat1642
34. Adams KR; Chauhan S; Patel DB; Clements VK; Wang Y; Jay SM; Edwards NJ; Ostrand-Rosenberg S; Fenselau C. (2018) Ubiquitin conjugation probed by inflammation in MDSC extracellular vesicles. J Proteome Res 17(1):315-324.
33. Jeyaram A; Jay SM. (2017) Preservation and storage stability of extracellular vesicles for therapeutic applications. AAPS Journal 20(1):1.
32. Lamichhane TN; Leung CA; Douti LY; Jay SM. (2017) Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs. Scientific Reports 7(1):13794.
31. Li L; Jay SM; Wang Y; Wu SW; Xiao Z. (2017) IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Scientific Reports 7(1):13365.
30. Jay SM; Vunjak-Novakovic G. (2017) Extracellular Vesicles and their Versatile Roles in Tissue Engineering. Tissue Engineering Part A 23(21-22):1210-1211.
29. Patel DB; Gray KM; Santharam Y; Lamichanne TN; Stroka KM; Jay SM. (2017) Impact of Cell Culture Parameters on Production and Vascularization Bioactivity of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Bioengineering and Translational Medicine 2(2):170-179.
28. Kuwahara G; Hashimoto T; Tsunami M; Yamamoto K; Assi R; Foster TR; Hanisch JJ; Bai H; Hu H; Protack CD; Hall MR; Schardt JS; Jay SM; Madri JA; Kodama S; Dardik A. (2017) CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler Thromb Vasc Biol. 37(6):1147-1156.
27. Schardt JS; Williams SC; Howard JL; Aloimonos CM; Bookstaver ML; Lamichhane TN; Sokic S; Liyasova MS; Hussain A; Lipkowitz S; Jay SM (2017) Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells. Molecular Pharmaceutics. 14(4):1047-1056.
26. Lamichhane TN; Jeyaram A; Patel DB; Parajuli B; Livingston NK; Arumugasaamy N; Schardt JS; Jay SM. (2016) Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication. Cellular and Molecular Bioengineering 9(3):315-324. Featured in special issue: 2016 Young Innovators in Cellular and Molecular Bioengineering.
25. Lamichhane TN; Raiker RS; Jay SM. (2015) Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery. Molecular Pharmaceutics 12(10):3650-7.
24. Lamichhane TN; Sokic S; Schardt JS; Raiker RS; Lin JW; Jay SM. (2015) Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Engineering Part B 21(1):45-54.
Before UMD
23. Gattu A; Birkenfeld A; Iwakiri Y; Jay SM; Saltzman WM; Doll JA; Protiva P; Samuel V; Crawford SE; Chung CC. (2014) Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155(4):1373-85.
22. Jay SM; Lee RT (2013). Protein Engineering for Cardiovascular Therapeutics: Untapped Potential for Cardiac Repair. Circulation Research 113(7):933-43.
21. Jay SM; Murthy AC; Hawkins JF; Wortzel JR; Steinhauser ML; Alvarez LM; Gannon J; Macrae CM; Griffith LG; Lee RT (2013). An engineered bivalent Neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation 128(2):152-61.
20. Loffredo FS; Steinhauser ML; Jay SM; Gannon J; Pancoast JR; Yalamanchi P; Sinha M; Dall'osso C; Khong D; Shadrach JL; Miller CM; Singer BS; Stewart A; Psychogios N; Gerszten RE; Hartigan AJ; Kim MJ; Serwold T; Wagers AJ; Lee RT (2013). Growth Differentiation Factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153(4):828-39.
19. Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. Nature Materials 11(10):895-905.
18. Jay SM; Lee RT. (2011) Patching up the myocardium. Circulation Research 109:480-481.
17. Park J; Mattessich T; Jay SM; Agawu A; Saltzman WM; Fahmy TM (2011). Improved cellular targeting of PLGA nanoparticles via novel surfactants that facilitate enhanced surface ligand display. Journal of Controlled Release 156(1):109-15.
16. Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.
15. Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.
14. Jay SM; Skokos EA; Zheng J; Knox K; Kyriakides TR. (2010) Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. Journal of Biomedical Materials Research Part A 93(1):189-99.
13. Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.
12. Jay SM; Saltzman WM. (2009) Shining light on a new class of hydrogels. Nature Biotechnology 27(6):543-4.
11. Bertram JP; Jay SM; Hynes SR; Rauch MF; Robinson R; Lavik EB. (2009) Functionalized Poly(lactic-co-glycolic acid): A Versatile Biomaterial for Drug Delivery and Tissue Engineering Without Compromising Biocompatibility. Acta Biomaterialia 5(8):2860-2871.
10. Long JB; Jay SM; Segal SS; Madri JA. (2009) VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation. Developmental Biology 334(1):119-32.
9. Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.
8. Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.
7. Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.
6. Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.
5. Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. American Journal of Pathology 171:2:632-40.
4. Stern E; Jay S; Bertram J; Boese B; Kretzschmar I; Turner-Evans D; Dietz C; LaVan DA; Malinski T; Fahmy T; Reed MA. (2006) Electropolymerization on Microelectrodes: Functionalization Technique for Selective Protein and DNA Conjugation. Analytical Chemistry 78:6340-6346.
3. Jay SM; Peevy NJ; Jenkins TC; Burg KJL. (2006) Biodegradable Microparticles Based on Poly(D,L-Lactic Acid) as a Protective Transport System in Ruminant Digestion. Pharmaceutical Development and Technology 11:485-491.
2. Vincent K; Wang Q; Jay S; Hobbs K; Rymond BC. (2003) Genetic Interactions With CLF1 Identify Additional Pre-mRNA Splicing Factors and a Link Between Activators of Yeast Vesicular Transport and Splicing. Genetics 164:895-907.
1. Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.
Jay Lab at UMD
38. Lamichhane TN; Jay SM. (2018) Production of Extracellular Vesicles Loaded with Therapeutic Cargo. Methods in Molecular Biology 1831:37-47.
37. Jay SM (2018) A New Hope for chronic myocardial ischemia. Science Translational Medicine 10(449):eaau1975
36. Jay SM (2018) Slow and steady wins the race. Science Translational Medicine 10(441):eaat8530
35. Jay SM (2018) An EVolving approach to directed enzyme prodrug therapy for cancer. Science Translational Medicine 10(433):eaat1642
34. Adams KR; Chauhan S; Patel DB; Clements VK; Wang Y; Jay SM; Edwards NJ; Ostrand-Rosenberg S; Fenselau C. (2018) Ubiquitin conjugation probed by inflammation in MDSC extracellular vesicles. J Proteome Res 17(1):315-324.
33. Jeyaram A; Jay SM. (2017) Preservation and storage stability of extracellular vesicles for therapeutic applications. AAPS Journal 20(1):1.
32. Lamichhane TN; Leung CA; Douti LY; Jay SM. (2017) Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs. Scientific Reports 7(1):13794.
31. Li L; Jay SM; Wang Y; Wu SW; Xiao Z. (2017) IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Scientific Reports 7(1):13365.
30. Jay SM; Vunjak-Novakovic G. (2017) Extracellular Vesicles and their Versatile Roles in Tissue Engineering. Tissue Engineering Part A 23(21-22):1210-1211.
29. Patel DB; Gray KM; Santharam Y; Lamichanne TN; Stroka KM; Jay SM. (2017) Impact of Cell Culture Parameters on Production and Vascularization Bioactivity of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Bioengineering and Translational Medicine 2(2):170-179.
28. Kuwahara G; Hashimoto T; Tsunami M; Yamamoto K; Assi R; Foster TR; Hanisch JJ; Bai H; Hu H; Protack CD; Hall MR; Schardt JS; Jay SM; Madri JA; Kodama S; Dardik A. (2017) CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler Thromb Vasc Biol. 37(6):1147-1156.
27. Schardt JS; Williams SC; Howard JL; Aloimonos CM; Bookstaver ML; Lamichhane TN; Sokic S; Liyasova MS; Hussain A; Lipkowitz S; Jay SM (2017) Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells. Molecular Pharmaceutics. 14(4):1047-1056.
26. Lamichhane TN; Jeyaram A; Patel DB; Parajuli B; Livingston NK; Arumugasaamy N; Schardt JS; Jay SM. (2016) Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication. Cellular and Molecular Bioengineering 9(3):315-324. Featured in special issue: 2016 Young Innovators in Cellular and Molecular Bioengineering.
25. Lamichhane TN; Raiker RS; Jay SM. (2015) Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery. Molecular Pharmaceutics 12(10):3650-7.
24. Lamichhane TN; Sokic S; Schardt JS; Raiker RS; Lin JW; Jay SM. (2015) Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Engineering Part B 21(1):45-54.
Before UMD
23. Gattu A; Birkenfeld A; Iwakiri Y; Jay SM; Saltzman WM; Doll JA; Protiva P; Samuel V; Crawford SE; Chung CC. (2014) Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155(4):1373-85.
22. Jay SM; Lee RT (2013). Protein Engineering for Cardiovascular Therapeutics: Untapped Potential for Cardiac Repair. Circulation Research 113(7):933-43.
21. Jay SM; Murthy AC; Hawkins JF; Wortzel JR; Steinhauser ML; Alvarez LM; Gannon J; Macrae CM; Griffith LG; Lee RT (2013). An engineered bivalent Neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation 128(2):152-61.
20. Loffredo FS; Steinhauser ML; Jay SM; Gannon J; Pancoast JR; Yalamanchi P; Sinha M; Dall'osso C; Khong D; Shadrach JL; Miller CM; Singer BS; Stewart A; Psychogios N; Gerszten RE; Hartigan AJ; Kim MJ; Serwold T; Wagers AJ; Lee RT (2013). Growth Differentiation Factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153(4):828-39.
19. Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. Nature Materials 11(10):895-905.
18. Jay SM; Lee RT. (2011) Patching up the myocardium. Circulation Research 109:480-481.
17. Park J; Mattessich T; Jay SM; Agawu A; Saltzman WM; Fahmy TM (2011). Improved cellular targeting of PLGA nanoparticles via novel surfactants that facilitate enhanced surface ligand display. Journal of Controlled Release 156(1):109-15.
16. Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.
15. Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.
14. Jay SM; Skokos EA; Zheng J; Knox K; Kyriakides TR. (2010) Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. Journal of Biomedical Materials Research Part A 93(1):189-99.
13. Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.
12. Jay SM; Saltzman WM. (2009) Shining light on a new class of hydrogels. Nature Biotechnology 27(6):543-4.
11. Bertram JP; Jay SM; Hynes SR; Rauch MF; Robinson R; Lavik EB. (2009) Functionalized Poly(lactic-co-glycolic acid): A Versatile Biomaterial for Drug Delivery and Tissue Engineering Without Compromising Biocompatibility. Acta Biomaterialia 5(8):2860-2871.
10. Long JB; Jay SM; Segal SS; Madri JA. (2009) VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation. Developmental Biology 334(1):119-32.
9. Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.
8. Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.
7. Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.
6. Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.
5. Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. American Journal of Pathology 171:2:632-40.
4. Stern E; Jay S; Bertram J; Boese B; Kretzschmar I; Turner-Evans D; Dietz C; LaVan DA; Malinski T; Fahmy T; Reed MA. (2006) Electropolymerization on Microelectrodes: Functionalization Technique for Selective Protein and DNA Conjugation. Analytical Chemistry 78:6340-6346.
3. Jay SM; Peevy NJ; Jenkins TC; Burg KJL. (2006) Biodegradable Microparticles Based on Poly(D,L-Lactic Acid) as a Protective Transport System in Ruminant Digestion. Pharmaceutical Development and Technology 11:485-491.
2. Vincent K; Wang Q; Jay S; Hobbs K; Rymond BC. (2003) Genetic Interactions With CLF1 Identify Additional Pre-mRNA Splicing Factors and a Link Between Activators of Yeast Vesicular Transport and Splicing. Genetics 164:895-907.
1. Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.
