Publications (Pubmed)(Google Scholar)
2023
75. Born LJ; Bengali S; Hsu ATW; Abadchi S; Chang K; Lay F; Matsangos A; Johnson C; Jay SM; Harmon JW. (2023) Chitosan particles complexed with CAF-HIF-1a plasmids increase angiogenesis and improve wound healing. International Journal of Molecular Sciences 24:14095.
74. Pirolli NH; Reus LSC; Mamczarz Z; Khan S; Bentley WE; Jay SM. (2023) High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy. Biotechnology and Bioengineering
73. Dutta D; Pirolli NH; Levy D; Tsao J; Seecharan N; Xu X; Wang Z; Jia X; Jay SM. (2023) Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity. Biomaterials Science
72. Levy D; Abadchi SN; Shababi N; Ravari MM; Pirolli NH; Bergeron C; Obiorah A; Mokhtari-Esbuie F; Gheshlaghi S; Abraham JM; Smith IM; Powsner EH; Solomon TJ; Harmon JW; Jay SM. (2023) Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism. Advanced Healthcare Materials e2300879.
71. Kronstadt SM; Patel DB; Born LJ; Levy D; Lerman MJ; Mahadik B; McLoughlin ST; Fasuyi A; Fowlkes L; Hoorens van Heyningen L; Aranda A; Abadchi SN; Chang KH; Hsu ATW; Bengali S; Harmon JW; Fisher JP; Jay SM. (2023) Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity. Advanced Healthcare Materials e2300584.
70. Kronstadt SM; Hoorens van Heyningen L; Aranda A; Jay SM. (2023) Assessment of anti-inflammatory bioactivity of extracellular vesicles is susceptible to error via media component contamination. Cytotherapy 25(4):387-396.
2022
69. Levy D; Jeyaram A; Born LJ; Chang K; Abadchi S; Hsu ATW; Solomon T; Aranda A; Harmon JW; Jay SM. (2022) The Impact of Storage Condition and Duration on Bioactivity of Mesenchymal Stromal Cell Extracellular Vesicles. Cytotherapy S1465-3249(22)01025-8.
68. Pottash AE; Levy D; Jeyaram A; Kuo L; Kronstadt SM; Chao W; Jay SM. (2022) Combinatorial microRNA loading into extracellular vesicles for increased anti-inflammatory efficacy. ncRNA 8(5):71.
67. Adediran S; Wang L; Khan MA; Guang W; Fan X; Dan H; Qi J; Jay SM; Carrier F; Hussain A. (2022) Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. Cancers 14 (19):4626.
66. Kronstadt SM; Jay SM; Jeyaram A. (2022) Extracellular vesicle loading via pH-gradient modification. Methods in Molecular Biology 2504:231-239.
65. Born LJ; McLoughlin ST; Dutta D; Mahadik B; Jia X, Fisher JP, Jay SM. (2022) Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels. Journal of Biomedical Materials Research: Part A
2021
64. Wang S; Yang Y; Suen A; Zhu J; Williams B; Hu J; Chen F; Kozar R; Shen S; Li Z; Jeyaram A; Jay SM; Zou L; Chao W. (2021) Role of Extracellular MicroRNA-146a-5p in Host Innate Immunity and Bacterial Sepsis. iScience
63. Oliva Chávez AS; Wang X; Marnin L; Archer N; Hammond HL; McClure Carroll EE; Shaw DK; Tully BG; Buskirk AD; Ford SL; Butler LR; Shahi P; Morozova K: Clement CC; Lawres L: O’Neal AJ: Ben Mamoun C; Mason KL; Hobbs B; Scoles GA; Barry EM; Sonenshine D: Pal U; Valenzuela J; Sztein MB; Pasetti MF; Levin ML; Kotsyfakis M; Jay SM; Huntley JF; Miller LS; Santambrogio L; Pedra JHF. (2021) Tick Extracellular Vesicles Enable Arthropod Feeding and Promote Distinct Outcomes of Bacterial Infection. Nature Communications 12(1):3696
62. Kronstadt SK; Pottash AE; Levy D; Wang S; Chao W; Jay SM. (2021) Therapeutic Potential of Extracellular Vesicles for Sepsis Treatment. Advanced Therapeutics 4(7):2000259
61. Born LJ; Chang K; Shoureshi P: Lay F; Bengali S; Hsu ATW; Abadchi S; Harmon JW; Jay SM. (2021) HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing. Advanced Healthcare Materials e2002070
60. Pirolli NH; Bentley WE; Jay SM (2021) Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics. Advanced Biology 5(7):e2000540
59. Dutta D; Khan N; Wu J; Jay SM. (2021) Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy. Trends in Neurosciences 44(6):492-506
2020
58. Shimada BK; Yang Y; Zhu J; Wang S; Suen A; Kronstadt SM; Jeyaram A; Jay SM; Zou L; Chao W. (2020) Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction. Immunohorizons 4(9):561-572.
57. Hauk P; Stephens K; McKay R; Virgile C; VanArsdale E; #Pottash AE; Schardt JS; Jay SM; Sintim HO; Bentley WE. (2020) Homologous quorum sensing regulatory circuit (hQSRC): A dual-input genetic controller for modulating quorum sensing (QS)-mediated protein expression in E. coli. ACS Synthetic Biology 9(10):2692-2702.
56. Jay SM. (2020) Introduction to Editorial Board Member: W. Mark Saltzman. Bioengineering and Translational Medicine e10174.
55. Born LJ; Harmon JW; Jay SM. (2020) Therapeutic Potential of Extracellular Vesicle-Associated Long Non-Coding RNA. Bioengineering and Translational Medicine e10172. Featured in “Futures” special issue.
54. Jeyaram A; Lamichhane TN; Wang S; Dahal E; Kronstadt SM; Levy D; Parajuli B; Knudsen D; Chao W; Jay SM. (2020) Enhanced loading of functional miRNA cargo via pH-gradient modification of extracellular vesicles. Molecular Therapy 28(3):975-985.
2019
53. Russell AE;...Jay SM;...Vader P. (2019) Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: An ISEV Position Paper arising from the ISEV Membranes and EVs Workshop. Journal of Extracellular Vesicles. 8(1):1684862.
52. Piard C; Jeyaram A; Liu Y; Caccamese J; Jay SM; Chen Y; Fisher JP. (2019) 3D printed HUVECs/MSCs cocultures impact cellular interactions and angiogenesis depending on cell-cell distance. Biomaterials. 222:119423.
51. Yeung E; Fukunushi T; Bai Y; Bedja D; Pitaktong I; Mattson G; Jeyaram A; Lui C; Ong CS; Inoue T; Matsushita H; Abdollahi S; Jay SM; Hibino N. (2019) Cardiac regeneration using human iPSC-derived biomaterial-free 3D bioprinted cardiac patch in vivo. Journal of Tissue Engineering and Regenerative Medicine. 13(11):2031-2039.
50. Schardt JS; Noonan-Shueh M; Oubaid JM; Pottash AE; Williams SC; Hussain A; Lapidus RS; Lipkowitz S; Jay SM. (2019) HER3-targeted affibodies with optimized formats reduce ovarian cancer progression in a mouse xenograft model. AAPS Journal. 21(3):48.
49. Bai Y; Lui C; Yeung E; Matsushita H; Ong CS; Jeyaram A; Pitaktong I; Inoue T; Mohamed Z; DiSilvestre D; Jay SM; Tung L; Tomaselli G; Ma C; Hibino N. (2019) A Net Mold-based Method of Biomaterial Free Three-Dimensional Cardiac Tissue Creation. Tissue Engineering Part C. 25(4):243-252.
48. Jay SM. (2019) Both sides of the CRISPR coin. Science Translational Medicine 11(481):eaaw5332.
47. Pottash AE; Kuffner C; Noonan-Shueh M; Jay SM (2019) Protein-based Vehicles for Biomimetic RNAi Delivery. Journal of Biological Engineering. 13:19. Featured in special issue: Emerging Leaders in Biological Engineering
46. Jay SM. (2019) Protein silencing to stop a "silent killer". Science Translational Medicine 11(473):eaaw0529.
45. Patel DB; Luthers CR; Lerman MJ; Fisher JP; Jay SM. (2019) Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system. Acta Biomaterialia. Featured in special issue: Cell and Tissue Biofabrication 95:236-244.
2018
44. Thery C; Witwer KW…Jay SM…Zuba-Surma EK. (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7(1):1535750.
43. Jay SM. (2018) A large (scale) advance for small RNA therapeutics. Science Translational Medicine 10(465):eaav3895.
42. Xu J; Feng Y; Conn O; Jeyaram A; Jay SM; Zou L; Chao W. (2018) Circulating plasma extracellular vesicles from septic mice induce inflammation via miRNA- and TLR7-dependent mechanisms. Journal of Immunology 201(11):3392-3400.
41. Patel DB; Santoro M; Born LJ; Fisher JP; Jay SM. (2018) Towards Rationally Designed Biomanufacturing of Therapeutic Extracellular Vesicles: Impact of the Bioproduction Microenvironment. Biotechnology Advances. 36(8):2051-9.
40. McKay R; Ghodasra M; Schardt JS; Quan D; Pottash AE; Shang W; Jay SM; Payne GF; Chang MW; March JC; Bentley WE. (2018) Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease. Bioengineering and Translational Medicine. 3(3):209-221.
39. Jay SM. (2018) Special delivery by ‘armored’ CAR-T. Science Translational Medicine 10(457):eaav0334
38. Lamichhane TN; Jay SM. (2018) Production of Extracellular Vesicles Loaded with Therapeutic Cargo. Methods in Molecular Biology 1831:37-47.
37. Jay SM (2018) A New Hope for chronic myocardial ischemia. Science Translational Medicine 10(449):eaau1975
36. Jay SM (2018) Slow and steady wins the race. Science Translational Medicine 10(441):eaat8530.
35. Jay SM (2018) An EVolving approach to directed enzyme prodrug therapy for cancer. Science Translational Medicine 10(433):eaat1642.
34. Adams KR; Chauhan S; Patel DB; Clements VK; Wang Y; Jay SM; Edwards NJ; Ostrand-Rosenberg S; Fenselau C. (2018) Ubiquitin conjugation probed by inflammation in MDSC extracellular vesicles. J Proteome Res 17(1):315-324.
2017
33. Jeyaram A; Jay SM. (2017) Preservation and storage stability of extracellular vesicles for therapeutic applications. AAPS Journal 20(1):1.
32. Lamichhane TN; Leung CA; Douti LY; Jay SM. (2017) Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs. Scientific Reports 7(1):13794.
31. Li L; Jay SM; Wang Y; Wu SW; Xiao Z. (2017) IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Scientific Reports 7(1):13365.
30. Jay SM; Vunjak-Novakovic G. (2017) Extracellular Vesicles and their Versatile Roles in Tissue Engineering. Tissue Engineering Part A 23(21-22):1210-1211.
29. Patel DB; Gray KM; Santharam Y; Lamichanne TN; Stroka KM; Jay SM. (2017) Impact of Cell Culture Parameters on Production and Vascularization Bioactivity of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Bioengineering and Translational Medicine 2(2):170-179.
28. Kuwahara G; Hashimoto T; Tsunami M; Yamamoto K; Assi R; Foster TR; Hanisch JJ; Bai H; Hu H; Protack CD; Hall MR; Schardt JS; Jay SM; Madri JA; Kodama S; Dardik A. (2017) CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler Thromb Vasc Biol. 37(6):1147-1156.
27. Schardt JS; Williams SC; Howard JL; Aloimonos CM; Bookstaver ML; Lamichhane TN; Sokic S; Liyasova MS; Hussain A; Lipkowitz S; Jay SM (2017) Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells. Molecular Pharmaceutics. 14(4):1047-1056.
2016
26. Lamichhane TN; Jeyaram A; Patel DB; Parajuli B; Livingston NK; Arumugasaamy N; Schardt JS; Jay SM. (2016) Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication. Cellular and Molecular Bioengineering 9(3):315-324. Featured in special issue: 2016 Young Innovators in Cellular and Molecular Bioengineering.
2015
25. Lamichhane TN; Raiker RS; Jay SM. (2015) Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery. Molecular Pharmaceutics 12(10):3650-7.
24. Lamichhane TN; Sokic S; Schardt JS; Raiker RS; Lin JW; Jay SM. (2015) Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Engineering Part B 21(1):45-54.
Before UMD
23. Gattu A; Birkenfeld A; Iwakiri Y; Jay SM; Saltzman WM; Doll JA; Protiva P; Samuel V; Crawford SE; Chung CC. (2014) Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155(4):1373-85.
22. Jay SM; Lee RT (2013). Protein Engineering for Cardiovascular Therapeutics: Untapped Potential for Cardiac Repair. Circulation Research 113(7):933-43.
21. Jay SM; Murthy AC; Hawkins JF; Wortzel JR; Steinhauser ML; Alvarez LM; Gannon J; Macrae CM; Griffith LG; Lee RT (2013). An engineered bivalent Neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation 128(2):152-61.
20. Loffredo FS; Steinhauser ML; Jay SM; Gannon J; Pancoast JR; Yalamanchi P; Sinha M; Dall'osso C; Khong D; Shadrach JL; Miller CM; Singer BS; Stewart A; Psychogios N; Gerszten RE; Hartigan AJ; Kim MJ; Serwold T; Wagers AJ; Lee RT (2013). Growth Differentiation Factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153(4):828-39.
19. Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. Nature Materials 11(10):895-905.
18. Jay SM; Lee RT. (2011) Patching up the myocardium. Circulation Research 109:480-481.
17. Park J; Mattessich T; Jay SM; Agawu A; Saltzman WM; Fahmy TM (2011). Improved cellular targeting of PLGA nanoparticles via novel surfactants that facilitate enhanced surface ligand display. Journal of Controlled Release 156(1):109-15.
16. Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.
15. Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.
14. Jay SM; Skokos EA; Zheng J; Knox K; Kyriakides TR. (2010) Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. Journal of Biomedical Materials Research Part A 93(1):189-99.
13. Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.
12. Jay SM; Saltzman WM. (2009) Shining light on a new class of hydrogels. Nature Biotechnology 27(6):543-4.
11. Bertram JP; Jay SM; Hynes SR; Rauch MF; Robinson R; Lavik EB. (2009) Functionalized Poly(lactic-co-glycolic acid): A Versatile Biomaterial for Drug Delivery and Tissue Engineering Without Compromising Biocompatibility. Acta Biomaterialia 5(8):2860-2871.
10. Long JB; Jay SM; Segal SS; Madri JA. (2009) VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation. Developmental Biology 334(1):119-32.
9. Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.
8. Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.
7. Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.
6. Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.
5. Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. American Journal of Pathology 171:2:632-40.
4. Stern E; Jay S; Bertram J; Boese B; Kretzschmar I; Turner-Evans D; Dietz C; LaVan DA; Malinski T; Fahmy T; Reed MA. (2006) Electropolymerization on Microelectrodes: Functionalization Technique for Selective Protein and DNA Conjugation. Analytical Chemistry 78:6340-6346.
3. Jay SM; Peevy NJ; Jenkins TC; Burg KJL. (2006) Biodegradable Microparticles Based on Poly(D,L-Lactic Acid) as a Protective Transport System in Ruminant Digestion. Pharmaceutical Development and Technology 11:485-491.
2. Vincent K; Wang Q; Jay S; Hobbs K; Rymond BC. (2003) Genetic Interactions With CLF1 Identify Additional Pre-mRNA Splicing Factors and a Link Between Activators of Yeast Vesicular Transport and Splicing. Genetics 164:895-907.
1. Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.
2023
75. Born LJ; Bengali S; Hsu ATW; Abadchi S; Chang K; Lay F; Matsangos A; Johnson C; Jay SM; Harmon JW. (2023) Chitosan particles complexed with CAF-HIF-1a plasmids increase angiogenesis and improve wound healing. International Journal of Molecular Sciences 24:14095.
74. Pirolli NH; Reus LSC; Mamczarz Z; Khan S; Bentley WE; Jay SM. (2023) High performance anion exchange chromatography purification of probiotic bacterial extracellular vesicles enhances purity and anti-inflammatory efficacy. Biotechnology and Bioengineering
73. Dutta D; Pirolli NH; Levy D; Tsao J; Seecharan N; Xu X; Wang Z; Jia X; Jay SM. (2023) Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity. Biomaterials Science
72. Levy D; Abadchi SN; Shababi N; Ravari MM; Pirolli NH; Bergeron C; Obiorah A; Mokhtari-Esbuie F; Gheshlaghi S; Abraham JM; Smith IM; Powsner EH; Solomon TJ; Harmon JW; Jay SM. (2023) Induced pluripotent stem cell-derived extracellular vesicles promote wound repair in a diabetic mouse model via an anti-inflammatory immunomodulatory mechanism. Advanced Healthcare Materials e2300879.
71. Kronstadt SM; Patel DB; Born LJ; Levy D; Lerman MJ; Mahadik B; McLoughlin ST; Fasuyi A; Fowlkes L; Hoorens van Heyningen L; Aranda A; Abadchi SN; Chang KH; Hsu ATW; Bengali S; Harmon JW; Fisher JP; Jay SM. (2023) Mesenchymal stem cell culture within perfusion bioreactors incorporating 3D-printed scaffolds enables improved extracellular vesicle yield with preserved bioactivity. Advanced Healthcare Materials e2300584.
70. Kronstadt SM; Hoorens van Heyningen L; Aranda A; Jay SM. (2023) Assessment of anti-inflammatory bioactivity of extracellular vesicles is susceptible to error via media component contamination. Cytotherapy 25(4):387-396.
2022
69. Levy D; Jeyaram A; Born LJ; Chang K; Abadchi S; Hsu ATW; Solomon T; Aranda A; Harmon JW; Jay SM. (2022) The Impact of Storage Condition and Duration on Bioactivity of Mesenchymal Stromal Cell Extracellular Vesicles. Cytotherapy S1465-3249(22)01025-8.
68. Pottash AE; Levy D; Jeyaram A; Kuo L; Kronstadt SM; Chao W; Jay SM. (2022) Combinatorial microRNA loading into extracellular vesicles for increased anti-inflammatory efficacy. ncRNA 8(5):71.
67. Adediran S; Wang L; Khan MA; Guang W; Fan X; Dan H; Qi J; Jay SM; Carrier F; Hussain A. (2022) Co-Targeting ErbB Receptors and the PI3K/AKT Axis in Androgen-Independent Taxane-Sensitive and Taxane-Resistant Human Prostate Cancer Cells. Cancers 14 (19):4626.
66. Kronstadt SM; Jay SM; Jeyaram A. (2022) Extracellular vesicle loading via pH-gradient modification. Methods in Molecular Biology 2504:231-239.
65. Born LJ; McLoughlin ST; Dutta D; Mahadik B; Jia X, Fisher JP, Jay SM. (2022) Sustained Released of Bioactive Mesenchymal Stromal Cell-Derived Extracellular Vesicles from 3D-Printed Gelatin Methacrylate Hydrogels. Journal of Biomedical Materials Research: Part A
2021
64. Wang S; Yang Y; Suen A; Zhu J; Williams B; Hu J; Chen F; Kozar R; Shen S; Li Z; Jeyaram A; Jay SM; Zou L; Chao W. (2021) Role of Extracellular MicroRNA-146a-5p in Host Innate Immunity and Bacterial Sepsis. iScience
63. Oliva Chávez AS; Wang X; Marnin L; Archer N; Hammond HL; McClure Carroll EE; Shaw DK; Tully BG; Buskirk AD; Ford SL; Butler LR; Shahi P; Morozova K: Clement CC; Lawres L: O’Neal AJ: Ben Mamoun C; Mason KL; Hobbs B; Scoles GA; Barry EM; Sonenshine D: Pal U; Valenzuela J; Sztein MB; Pasetti MF; Levin ML; Kotsyfakis M; Jay SM; Huntley JF; Miller LS; Santambrogio L; Pedra JHF. (2021) Tick Extracellular Vesicles Enable Arthropod Feeding and Promote Distinct Outcomes of Bacterial Infection. Nature Communications 12(1):3696
62. Kronstadt SK; Pottash AE; Levy D; Wang S; Chao W; Jay SM. (2021) Therapeutic Potential of Extracellular Vesicles for Sepsis Treatment. Advanced Therapeutics 4(7):2000259
61. Born LJ; Chang K; Shoureshi P: Lay F; Bengali S; Hsu ATW; Abadchi S; Harmon JW; Jay SM. (2021) HOTAIR-Loaded Mesenchymal Stem/Stromal Cell Extracellular Vesicles Enhance Angiogenesis and Wound Healing. Advanced Healthcare Materials e2002070
60. Pirolli NH; Bentley WE; Jay SM (2021) Bacterial Extracellular Vesicles and the Gut-Microbiota Brain Axis: Emerging Roles in Communication and Potential as Therapeutics. Advanced Biology 5(7):e2000540
59. Dutta D; Khan N; Wu J; Jay SM. (2021) Extracellular Vesicles as an Emerging Frontier in Spinal Cord Injury Pathobiology and Therapy. Trends in Neurosciences 44(6):492-506
2020
58. Shimada BK; Yang Y; Zhu J; Wang S; Suen A; Kronstadt SM; Jeyaram A; Jay SM; Zou L; Chao W. (2020) Extracellular miR-146a-5p Induces Cardiac Innate Immune Response and Cardiomyocyte Dysfunction. Immunohorizons 4(9):561-572.
57. Hauk P; Stephens K; McKay R; Virgile C; VanArsdale E; #Pottash AE; Schardt JS; Jay SM; Sintim HO; Bentley WE. (2020) Homologous quorum sensing regulatory circuit (hQSRC): A dual-input genetic controller for modulating quorum sensing (QS)-mediated protein expression in E. coli. ACS Synthetic Biology 9(10):2692-2702.
56. Jay SM. (2020) Introduction to Editorial Board Member: W. Mark Saltzman. Bioengineering and Translational Medicine e10174.
55. Born LJ; Harmon JW; Jay SM. (2020) Therapeutic Potential of Extracellular Vesicle-Associated Long Non-Coding RNA. Bioengineering and Translational Medicine e10172. Featured in “Futures” special issue.
54. Jeyaram A; Lamichhane TN; Wang S; Dahal E; Kronstadt SM; Levy D; Parajuli B; Knudsen D; Chao W; Jay SM. (2020) Enhanced loading of functional miRNA cargo via pH-gradient modification of extracellular vesicles. Molecular Therapy 28(3):975-985.
2019
53. Russell AE;...Jay SM;...Vader P. (2019) Biological membranes in EV biogenesis, stability, uptake, and cargo transfer: An ISEV Position Paper arising from the ISEV Membranes and EVs Workshop. Journal of Extracellular Vesicles. 8(1):1684862.
52. Piard C; Jeyaram A; Liu Y; Caccamese J; Jay SM; Chen Y; Fisher JP. (2019) 3D printed HUVECs/MSCs cocultures impact cellular interactions and angiogenesis depending on cell-cell distance. Biomaterials. 222:119423.
51. Yeung E; Fukunushi T; Bai Y; Bedja D; Pitaktong I; Mattson G; Jeyaram A; Lui C; Ong CS; Inoue T; Matsushita H; Abdollahi S; Jay SM; Hibino N. (2019) Cardiac regeneration using human iPSC-derived biomaterial-free 3D bioprinted cardiac patch in vivo. Journal of Tissue Engineering and Regenerative Medicine. 13(11):2031-2039.
50. Schardt JS; Noonan-Shueh M; Oubaid JM; Pottash AE; Williams SC; Hussain A; Lapidus RS; Lipkowitz S; Jay SM. (2019) HER3-targeted affibodies with optimized formats reduce ovarian cancer progression in a mouse xenograft model. AAPS Journal. 21(3):48.
49. Bai Y; Lui C; Yeung E; Matsushita H; Ong CS; Jeyaram A; Pitaktong I; Inoue T; Mohamed Z; DiSilvestre D; Jay SM; Tung L; Tomaselli G; Ma C; Hibino N. (2019) A Net Mold-based Method of Biomaterial Free Three-Dimensional Cardiac Tissue Creation. Tissue Engineering Part C. 25(4):243-252.
48. Jay SM. (2019) Both sides of the CRISPR coin. Science Translational Medicine 11(481):eaaw5332.
47. Pottash AE; Kuffner C; Noonan-Shueh M; Jay SM (2019) Protein-based Vehicles for Biomimetic RNAi Delivery. Journal of Biological Engineering. 13:19. Featured in special issue: Emerging Leaders in Biological Engineering
46. Jay SM. (2019) Protein silencing to stop a "silent killer". Science Translational Medicine 11(473):eaaw0529.
45. Patel DB; Luthers CR; Lerman MJ; Fisher JP; Jay SM. (2019) Enhanced extracellular vesicle production and ethanol-mediated vascularization bioactivity via a 3D-printed scaffold-perfusion bioreactor system. Acta Biomaterialia. Featured in special issue: Cell and Tissue Biofabrication 95:236-244.
2018
44. Thery C; Witwer KW…Jay SM…Zuba-Surma EK. (2018) Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines. Journal of Extracellular Vesicles 7(1):1535750.
43. Jay SM. (2018) A large (scale) advance for small RNA therapeutics. Science Translational Medicine 10(465):eaav3895.
42. Xu J; Feng Y; Conn O; Jeyaram A; Jay SM; Zou L; Chao W. (2018) Circulating plasma extracellular vesicles from septic mice induce inflammation via miRNA- and TLR7-dependent mechanisms. Journal of Immunology 201(11):3392-3400.
41. Patel DB; Santoro M; Born LJ; Fisher JP; Jay SM. (2018) Towards Rationally Designed Biomanufacturing of Therapeutic Extracellular Vesicles: Impact of the Bioproduction Microenvironment. Biotechnology Advances. 36(8):2051-9.
40. McKay R; Ghodasra M; Schardt JS; Quan D; Pottash AE; Shang W; Jay SM; Payne GF; Chang MW; March JC; Bentley WE. (2018) Genetically Engineered Bacteria as Vehicles for Localized Delivery of Therapeutics: An Application for Crohn’s Disease. Bioengineering and Translational Medicine. 3(3):209-221.
39. Jay SM. (2018) Special delivery by ‘armored’ CAR-T. Science Translational Medicine 10(457):eaav0334
38. Lamichhane TN; Jay SM. (2018) Production of Extracellular Vesicles Loaded with Therapeutic Cargo. Methods in Molecular Biology 1831:37-47.
37. Jay SM (2018) A New Hope for chronic myocardial ischemia. Science Translational Medicine 10(449):eaau1975
36. Jay SM (2018) Slow and steady wins the race. Science Translational Medicine 10(441):eaat8530.
35. Jay SM (2018) An EVolving approach to directed enzyme prodrug therapy for cancer. Science Translational Medicine 10(433):eaat1642.
34. Adams KR; Chauhan S; Patel DB; Clements VK; Wang Y; Jay SM; Edwards NJ; Ostrand-Rosenberg S; Fenselau C. (2018) Ubiquitin conjugation probed by inflammation in MDSC extracellular vesicles. J Proteome Res 17(1):315-324.
2017
33. Jeyaram A; Jay SM. (2017) Preservation and storage stability of extracellular vesicles for therapeutic applications. AAPS Journal 20(1):1.
32. Lamichhane TN; Leung CA; Douti LY; Jay SM. (2017) Ethanol Induces Enhanced Vascularization Bioactivity of Endothelial Cell-Derived Extracellular Vesicles via Regulation of MicroRNAs and Long Non-Coding RNAs. Scientific Reports 7(1):13794.
31. Li L; Jay SM; Wang Y; Wu SW; Xiao Z. (2017) IL-12 stimulates CTLs to secrete exosomes capable of activating bystander CD8+ T cells. Scientific Reports 7(1):13365.
30. Jay SM; Vunjak-Novakovic G. (2017) Extracellular Vesicles and their Versatile Roles in Tissue Engineering. Tissue Engineering Part A 23(21-22):1210-1211.
29. Patel DB; Gray KM; Santharam Y; Lamichanne TN; Stroka KM; Jay SM. (2017) Impact of Cell Culture Parameters on Production and Vascularization Bioactivity of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Bioengineering and Translational Medicine 2(2):170-179.
28. Kuwahara G; Hashimoto T; Tsunami M; Yamamoto K; Assi R; Foster TR; Hanisch JJ; Bai H; Hu H; Protack CD; Hall MR; Schardt JS; Jay SM; Madri JA; Kodama S; Dardik A. (2017) CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler Thromb Vasc Biol. 37(6):1147-1156.
27. Schardt JS; Williams SC; Howard JL; Aloimonos CM; Bookstaver ML; Lamichhane TN; Sokic S; Liyasova MS; Hussain A; Lipkowitz S; Jay SM (2017) Engineered Multivalency Enhances Affibody-Based HER3 Inhibition and Downregulation in Cancer Cells. Molecular Pharmaceutics. 14(4):1047-1056.
2016
26. Lamichhane TN; Jeyaram A; Patel DB; Parajuli B; Livingston NK; Arumugasaamy N; Schardt JS; Jay SM. (2016) Oncogene Knockdown via Active Loading of Small RNAs into Extracellular Vesicles by Sonication. Cellular and Molecular Bioengineering 9(3):315-324. Featured in special issue: 2016 Young Innovators in Cellular and Molecular Bioengineering.
2015
25. Lamichhane TN; Raiker RS; Jay SM. (2015) Exogenous DNA Loading into Extracellular Vesicles via Electroporation is Size-Dependent and Enables Limited Gene Delivery. Molecular Pharmaceutics 12(10):3650-7.
24. Lamichhane TN; Sokic S; Schardt JS; Raiker RS; Lin JW; Jay SM. (2015) Emerging roles for extracellular vesicles in tissue engineering and regenerative medicine. Tissue Engineering Part B 21(1):45-54.
Before UMD
23. Gattu A; Birkenfeld A; Iwakiri Y; Jay SM; Saltzman WM; Doll JA; Protiva P; Samuel V; Crawford SE; Chung CC. (2014) Pigment epithelium-derived factor (PEDF) suppresses IL-1β-mediated c-Jun N-terminal kinase (JNK) activation to improve hepatocyte insulin signaling. Endocrinology 155(4):1373-85.
22. Jay SM; Lee RT (2013). Protein Engineering for Cardiovascular Therapeutics: Untapped Potential for Cardiac Repair. Circulation Research 113(7):933-43.
21. Jay SM; Murthy AC; Hawkins JF; Wortzel JR; Steinhauser ML; Alvarez LM; Gannon J; Macrae CM; Griffith LG; Lee RT (2013). An engineered bivalent Neuregulin protects against doxorubicin-induced cardiotoxicity with reduced proneoplastic potential. Circulation 128(2):152-61.
20. Loffredo FS; Steinhauser ML; Jay SM; Gannon J; Pancoast JR; Yalamanchi P; Sinha M; Dall'osso C; Khong D; Shadrach JL; Miller CM; Singer BS; Stewart A; Psychogios N; Gerszten RE; Hartigan AJ; Kim MJ; Serwold T; Wagers AJ; Lee RT (2013). Growth Differentiation Factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell 153(4):828-39.
19. Park J; Wrzesinski SH; Stern E; Look M; Jay SM; Demento SL; Agawu A; Limon PL; Ferrandino AF; Flavell RA; Fahmy TM (2012). Enhanced anti-tumor activity by combination immunotherapy with sustained release of IL-2 and a TGF-β inhibitor from nanolipogel vehicles. Nature Materials 11(10):895-905.
18. Jay SM; Lee RT. (2011) Patching up the myocardium. Circulation Research 109:480-481.
17. Park J; Mattessich T; Jay SM; Agawu A; Saltzman WM; Fahmy TM (2011). Improved cellular targeting of PLGA nanoparticles via novel surfactants that facilitate enhanced surface ligand display. Journal of Controlled Release 156(1):109-15.
16. Jay SM; Kurtagic E; Alvarez LM; de Picciotto S; Sanchez E; Hawkins JF; Prince RN; Guerrero Y; Treasure CT; Lee RT; Griffith LG (2011). Engineered bivalent ligands to bias ErbB receptor-mediated signaling and phenotypes. Journal of Biological Chemistry 286(31):27729-40. Selected by Faculty of 1000.
15. Jay SM; Shepherd BR; Andrejecsk JW; Kyriakides TR; Pober JS; Saltzman WM (2010). Dual delivery of VEGF and MCP-1 to support endothelial cell transplantation for therapeutic vascularization. Biomaterials 31(11):3054-3062. Featured in Science Translational Medicine, 17 March 2010:Vol. 2, Issue 23, p. 23ec45. Editors' Choice: Protein Cocktail Nourishes New Vessels.
14. Jay SM; Skokos EA; Zheng J; Knox K; Kyriakides TR. (2010) Macrophage fusion leading to foreign body giant cell formation persists under phagocytic stimulation by microspheres in vitro and in vivo in mouse models. Journal of Biomedical Materials Research Part A 93(1):189-99.
13. Roh JD; Sawh-Martinez R; Brennan MP; Jay SM; Devine L; Yi T; Mirensky T; Rao DA; Udelsman B; Nelson GN; Hibino N; Shinoka T; Saltzman WM; Snyder E; Kyriakides TR; Pober JS; Breuer CK. (2010) Human Bone Marrow Cell Seeding Improves Outcomes of Tissue-Engineered Vascular Grafts through MCP-1 Mediated Monocyte Recruitment. PNAS 107(10):4669-74.
12. Jay SM; Saltzman WM. (2009) Shining light on a new class of hydrogels. Nature Biotechnology 27(6):543-4.
11. Bertram JP; Jay SM; Hynes SR; Rauch MF; Robinson R; Lavik EB. (2009) Functionalized Poly(lactic-co-glycolic acid): A Versatile Biomaterial for Drug Delivery and Tissue Engineering Without Compromising Biocompatibility. Acta Biomaterialia 5(8):2860-2871.
10. Long JB; Jay SM; Segal SS; Madri JA. (2009) VEGF-A and Semaphorin3A: Modulators of vascular sympathetic innervation. Developmental Biology 334(1):119-32.
9. Stern E; Jay SM; Demento S; Murelli R; Reed MA; Malinski T; Spiegel D; Mooney DJ; Fahmy TM. (2009) Spatiotemporal control over molecular delivery and cellular encapsulation from electropolymerized micro- and nanopatterned surfaces. Advanced Functional Materials 19(18):2888-2895.
8. Jay SM; Saltzman WM. (2009) Controlled Delivery of VEGF Via Modulation of Alginate Microparticle Ionic Crosslinking. Journal of Controlled Release 134(1):26-34.
7. Shepherd BR; Jay SM; Saltzman WM; Tellides G; Pober JS. (2009) Accelerated Synthetic Microvessel Remodeling by Co-Engraftment of Human Endothelial Cells and Vascular Smooth Muscle Cells. Tissue Engineering Part A 15(1):165-173. Featured in Advances in Tissue Engineering, Volume 1: Angiogenesis (2009), Peter C. Johnson and Antonios G. Mikos, eds.
6. Jay SM; Shepherd BR; Bertram JP; Pober JS; Saltzman WM. (2008) Engineering of Multifunctional Gels Integrating Highly Efficient Growth Factor Delivery with Endothelial Cell Transplantation. FASEB Journal 22(8):2949-56.
5. Jay SM; Skokos E; Laiwalla F; Krady M; Kyriakides TR. (2007) Foreign Body Giant Cell Formation Is Preceded by Lamellipodia Formation and Can Be Attenuated by Inhibition of Rac1 Activation. American Journal of Pathology 171:2:632-40.
4. Stern E; Jay S; Bertram J; Boese B; Kretzschmar I; Turner-Evans D; Dietz C; LaVan DA; Malinski T; Fahmy T; Reed MA. (2006) Electropolymerization on Microelectrodes: Functionalization Technique for Selective Protein and DNA Conjugation. Analytical Chemistry 78:6340-6346.
3. Jay SM; Peevy NJ; Jenkins TC; Burg KJL. (2006) Biodegradable Microparticles Based on Poly(D,L-Lactic Acid) as a Protective Transport System in Ruminant Digestion. Pharmaceutical Development and Technology 11:485-491.
2. Vincent K; Wang Q; Jay S; Hobbs K; Rymond BC. (2003) Genetic Interactions With CLF1 Identify Additional Pre-mRNA Splicing Factors and a Link Between Activators of Yeast Vesicular Transport and Splicing. Genetics 164:895-907.
1. Jay S; Fountain W; Cui Z; Mumper RJ. (2002) Transmucosal Delivery of Testosterone in Rabbits Using Novel Bi-Layer Mucoadhesive Wax-Film Composite Disks. Journal of Pharmaceutical Science 91:2016-2025.
