Biotherapeutic Development and Delivery LaboratorySteven M. Jay
Assistant Professor, Fischell Department of Bioengineering University of Maryland, College Park 3116 A. James Clark Hall 301-405-2829 smjay@umd.edu |
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Our research aims to uncover new biological insights towards the design and development of novel biotherapeutics (aka biopharmaceuticals), including proteins, extracellular vesicles (exosomes) and others. We also strive to develop new approaches to drug delivery and biomanufacturing using fundamental tools from both engineering and biology. Employing techniques in molecular biology, protein design and engineering, biomaterials and nanotechnology, we are primarily interested in developing new biotechnologies to address clinical needs in wound repair, cardiovascular disease, cancer, brain and spinal cord injuries, neurological diseases, osteoarthritis, and sepsis, among others. Overarching goals of the lab include developing therapeutics towards clinical translation and endowing trainees with the skills and knowledge necessary to become leaders in the biotechnology and pharmaceutical industries.
Recent Highlights
November 2018 - New publications: Acta Biomaterialia, Journal of Extracellular Vesicles (MISEV 2018)
October 2018 - New publications: J. Immunol, Biotech Adv, Bioengin Trans Med, Methods Mol Biol
July 2018 - Divya wins Student Travel Award, Anjana wins Career Development Award for BMES Annual Meeting
June 2018 - Anjana wins Best Poster award at World Preclinical Congress
April 2018 - Dr. Jay named UMD Graduate Faculty Mentor of the Year
April 2018 - Congrats to Dr. John Schardt on the successful defense of his PhD thesis!
April 2018 - Lab proposal to apply therapeutic EVs for diabetic wound healing recommended for funding by CDMRP PRMRP
April 2018 - Natalie wins NSF Graduate Fellowship; Eli receives Honorable Mention
March 2018 - Lab moves into new space in A. James Clark Hall
March 2018 - Lab awarded NIH R01 funding for work on controlled delivery of non-coding RNA cargo via EVs
March 2018 - Dr. Jay receives NSF CAREER Award to support therapeutic EV biomanufacturing research
March 2018 - Lab awarded funding from the Rivkin Center for Ovarian Cancer
February 2018 - Four new student awards! Congrats to Sonya, Natalie, and Jinan!
January 2018 - Dr. Jay named to Associate Scientific Advisory board of Science Translational Medicine
December 2017 - Anjana Jeyaram awarded PhRMA Fellowship to study pharmaceutical properties of extracellular vesicles
November 2017 - Special Issue of journal Tissue Engineering on impact of EVs published
October 2017 - Four new publications on EVs: Scientific Reports (x2), AAPS Journal, Journal of Proteome Research
July 2017 - Lab awarded funding for studying EVs in arthritis by Arthritis Foundation via Alpha Omicron Pi
June 2017 - Divya's paper on EV production published in Bioengineering and Translational Medicine
June 2017 - Lab awarded MPower seed funding for developing EVs for spinal cord injury treatment
June 2017 - Lab awarded funding from the Maryland Innovation Initiative for gene delivery for wound repair
May 2017 - John Schardt receives AAPS Fellowship to study cancer therapeutic development
April 2017 - New publication in ATVB highlighting cardiovascular drug delivery
March 2017 - John's paper published in Molecular Pharmaceutics on anti-cancer approaches
February 2017 - John Schardt receives 2017 PEGSummit Student Fellowship
December 2016 - Lab awarded funding from Elsa U. Pardee Foundation for cancer therapeutic development
October 2016 - Lab awarded funding from National Cancer Institute (NCI)
August 2016 - Dr. Jay named Cellular and Molecular Bioengineering Young Innovator
July 2016 - Tek's paper published in Cellular and Molecular Bioengineering on RNA interference via exosomes
June 2016 - Divya Patel awarded AHA Fellowship to study the exosome production microenvironment
See more in News...
Recent Highlights
November 2018 - New publications: Acta Biomaterialia, Journal of Extracellular Vesicles (MISEV 2018)
October 2018 - New publications: J. Immunol, Biotech Adv, Bioengin Trans Med, Methods Mol Biol
July 2018 - Divya wins Student Travel Award, Anjana wins Career Development Award for BMES Annual Meeting
June 2018 - Anjana wins Best Poster award at World Preclinical Congress
April 2018 - Dr. Jay named UMD Graduate Faculty Mentor of the Year
April 2018 - Congrats to Dr. John Schardt on the successful defense of his PhD thesis!
April 2018 - Lab proposal to apply therapeutic EVs for diabetic wound healing recommended for funding by CDMRP PRMRP
April 2018 - Natalie wins NSF Graduate Fellowship; Eli receives Honorable Mention
March 2018 - Lab moves into new space in A. James Clark Hall
March 2018 - Lab awarded NIH R01 funding for work on controlled delivery of non-coding RNA cargo via EVs
March 2018 - Dr. Jay receives NSF CAREER Award to support therapeutic EV biomanufacturing research
March 2018 - Lab awarded funding from the Rivkin Center for Ovarian Cancer
February 2018 - Four new student awards! Congrats to Sonya, Natalie, and Jinan!
January 2018 - Dr. Jay named to Associate Scientific Advisory board of Science Translational Medicine
December 2017 - Anjana Jeyaram awarded PhRMA Fellowship to study pharmaceutical properties of extracellular vesicles
November 2017 - Special Issue of journal Tissue Engineering on impact of EVs published
October 2017 - Four new publications on EVs: Scientific Reports (x2), AAPS Journal, Journal of Proteome Research
July 2017 - Lab awarded funding for studying EVs in arthritis by Arthritis Foundation via Alpha Omicron Pi
June 2017 - Divya's paper on EV production published in Bioengineering and Translational Medicine
June 2017 - Lab awarded MPower seed funding for developing EVs for spinal cord injury treatment
June 2017 - Lab awarded funding from the Maryland Innovation Initiative for gene delivery for wound repair
May 2017 - John Schardt receives AAPS Fellowship to study cancer therapeutic development
April 2017 - New publication in ATVB highlighting cardiovascular drug delivery
March 2017 - John's paper published in Molecular Pharmaceutics on anti-cancer approaches
February 2017 - John Schardt receives 2017 PEGSummit Student Fellowship
December 2016 - Lab awarded funding from Elsa U. Pardee Foundation for cancer therapeutic development
October 2016 - Lab awarded funding from National Cancer Institute (NCI)
August 2016 - Dr. Jay named Cellular and Molecular Bioengineering Young Innovator
July 2016 - Tek's paper published in Cellular and Molecular Bioengineering on RNA interference via exosomes
June 2016 - Divya Patel awarded AHA Fellowship to study the exosome production microenvironment
See more in News...
We are grateful to the following agencies/institutions for generously supporting our work:
