Biotherapeutic Development and Delivery LaboratorySteven M. Jay
Associate Professor, Fischell Department of Bioengineering University of Maryland, College Park 3116 A. James Clark Hall 301-405-2829 smjay@umd.edu |
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Our research aims to uncover new biological insights towards the design, production, and delivery of novel biotherapeutics and biomaterials. Our focus areas include extracellular vesicles (EVs, including exosomes), bacteria and live bacterial products such as outer membrane vesicles (OMVs), engineered protein therapeutics, and others. We strive to develop new drug delivery and biomanufacturing approaches using fundamental tools from both engineering and biology. Employing techniques in molecular biology, protein design, process engineering, and nanotechnology, we are primarily interested in developing new biotechnologies to address clinical needs in wound repair, cardiovascular disease, cancer, brain and spinal cord injuries, neurological diseases, osteoarthritis, and sepsis, among others. Overarching goals of the lab include developing therapeutics towards clinical translation and endowing trainees with the skills and knowledge necessary to become leaders in the biotechnology and pharmaceutical industries.
Recent Highlights
August 2021 - Lab awarded new R21 funding from NIH with collaborator Dr. Don DeVoe
May 2021 - Congrats to Dr. Louis Born on the successful defense of his PhD thesis! Next up, finishing the MD at UMB.
March 2021 - Congrats to Louis Born on receiving both an AHA Predoctoral Fellowship and NIH F30 fellowship!
February 2021 - Congrats to Dan Levy on receiving the Cosmos Club Scholar Award!
January 2021 - Lab awarded Phase 1 funding from Maryland Industrial Partnerships (MIPS) program
August 2020 - Congrats to Rachel Lee on the successful defense of her MS thesis and position at FZata!
June 2020 - Vaani recognized with Extraordinary Service Award
June 2020 - Dipankar awarded MSCRF Postdoctoral Fellowship
May 2020 - Steph awarded NIH T32 Fellowship
May 2020 - Lab awarded funding from FDA via University of Maryland CERSI
January 2020 - Lab awarded NIH R01 funding from NHLBI
December 2019 - New publication in Molecular Therapy
September 2019 - Congrats to Dr. Anjana Jeyaram on the successful defense of her PhD thesis and position at Novartis!
September 2019 - Lab awarded NIH RF1 funding from NIA
August 2019 - Congrats to Dr. Divya Patel on the successful defense of her PhD thesis and position at RoosterBio!
June 2019 - Lab receives RoosterBio hMSC Development Grant
May 2019 - Dr. Jay promoted to Associate Professor with tenure, effective July 2019
February 2019 - Lab awarded NIH R01 funding from NIGMS
January 2019 - Eli awarded NIH T32 Fellowship
June 2018 - Anjana wins Best Poster award at World Preclinical Congress
April 2018 - Dr. Jay named UMD Graduate Faculty Mentor of the Year
April 2018 - Congrats to Dr. John Schardt on the successful defense of his PhD thesis and postdoctoral position!
April 2018 - Proposal to apply therapeutic EVs for diabetic wound healing recommended for funding by CDMRP PRMRP
March 2018 - Lab moves into new space in A. James Clark Hall
March 2018 - Lab awarded NIH R01 funding for work on controlled delivery of non-coding RNA cargo via EVs
March 2018 - Dr. Jay receives NSF CAREER Award to support therapeutic EV biomanufacturing research
See more in News...
Recent Highlights
August 2021 - Lab awarded new R21 funding from NIH with collaborator Dr. Don DeVoe
May 2021 - Congrats to Dr. Louis Born on the successful defense of his PhD thesis! Next up, finishing the MD at UMB.
March 2021 - Congrats to Louis Born on receiving both an AHA Predoctoral Fellowship and NIH F30 fellowship!
February 2021 - Congrats to Dan Levy on receiving the Cosmos Club Scholar Award!
January 2021 - Lab awarded Phase 1 funding from Maryland Industrial Partnerships (MIPS) program
August 2020 - Congrats to Rachel Lee on the successful defense of her MS thesis and position at FZata!
June 2020 - Vaani recognized with Extraordinary Service Award
June 2020 - Dipankar awarded MSCRF Postdoctoral Fellowship
May 2020 - Steph awarded NIH T32 Fellowship
May 2020 - Lab awarded funding from FDA via University of Maryland CERSI
January 2020 - Lab awarded NIH R01 funding from NHLBI
December 2019 - New publication in Molecular Therapy
September 2019 - Congrats to Dr. Anjana Jeyaram on the successful defense of her PhD thesis and position at Novartis!
September 2019 - Lab awarded NIH RF1 funding from NIA
August 2019 - Congrats to Dr. Divya Patel on the successful defense of her PhD thesis and position at RoosterBio!
June 2019 - Lab receives RoosterBio hMSC Development Grant
May 2019 - Dr. Jay promoted to Associate Professor with tenure, effective July 2019
February 2019 - Lab awarded NIH R01 funding from NIGMS
January 2019 - Eli awarded NIH T32 Fellowship
June 2018 - Anjana wins Best Poster award at World Preclinical Congress
April 2018 - Dr. Jay named UMD Graduate Faculty Mentor of the Year
April 2018 - Congrats to Dr. John Schardt on the successful defense of his PhD thesis and postdoctoral position!
April 2018 - Proposal to apply therapeutic EVs for diabetic wound healing recommended for funding by CDMRP PRMRP
March 2018 - Lab moves into new space in A. James Clark Hall
March 2018 - Lab awarded NIH R01 funding for work on controlled delivery of non-coding RNA cargo via EVs
March 2018 - Dr. Jay receives NSF CAREER Award to support therapeutic EV biomanufacturing research
See more in News...
We are grateful to the following agencies/institutions/companies for generously supporting our work:
